Hyperpigmentation Risk Checker

Does Tranexamic Acid Cause Hyperpigmentation?

Evidence-based guidance on tranexamic acid and its risk of triggering or worsening dark spots, melasma, and post-inflammatory hyperpigmentation.

Risk level
LOW risk

Tranexamic acid is increasingly used for melasma and post-inflammatory hyperpigmentation. It is generally well tolerated and has a low risk of causing pigmentation issues.

How it can affect pigmentation

  • Plasmin inhibition reducing melanocyte activity
  • Anti-inflammatory
  • Low irritation potential

Usage advice

Tranexamic acid is suitable for leave-on serums and can be used day or night under sunscreen.

Recommendations

  • Use consistently for melasma-prone skin.
  • Pair with sunscreen and other brighteners if tolerated.
  • Always use sun protection if your skin tends to hyperpigment; we recommend a zinc oxide sunscreen.

Sources

  • Tranexamic acid for melasma. Taraz M, et al. J Cosmet Dermatol. 2021;20(12):3895-3901. link

Related ingredients

Azelaic AcidNiacinamide

Check a full product

Paste your full ingredient list into the analyzer to see how every ingredient scores together.

Analyze your product