Does Azelaic Acid Cause Hyperpigmentation?

Evidence-based guidance on azelaic acid and its risk of triggering or worsening dark spots, melasma, and post-inflammatory hyperpigmentation.

Risk level
LOW risk

Azelaic acid is a well-tolerated brightening agent with anti-inflammatory properties. It is suitable for acne, rosacea, and hyperpigmentation-prone skin.

How it can affect pigmentation

  • Tyrosinase inhibition
  • Anti-inflammatory
  • Antibacterial for acne-related PIH

Usage advice

Azelaic acid is suitable for day or night use. It is one of the lower-risk actives for darker skin tones.

Recommendations

  • Use morning or evening.
  • Pair with niacinamide or sunscreen for best results.
  • Always use sun protection if your skin tends to hyperpigment; we recommend a zinc oxide sunscreen.

Sources

  • Azelaic acid: a review of its use in acne and rosacea. Dall'Oglio F, et al. G Ital Dermatol Venereol. 2023;158(3):e20220411. link

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