Does Niacinamide Cause Hyperpigmentation?

Evidence-based guidance on niacinamide and its risk of triggering or worsening dark spots, melasma, and post-inflammatory hyperpigmentation.

Risk level

LOW risk

Niacinamide is one of the best-tolerated brightening ingredients. It supports barrier function, reduces inflammation, and can inhibit melanosome transfer without significant irritation risk.

How it can affect pigmentation

Anti-inflammatory and barrier-supportive
Inhibits melanosome transfer to keratinocytes
Rarely causes flushing at high concentrations

Usage advice

Niacinamide is suitable for both day and night use and pairs well with most other actives. It is a low-risk choice for hyperpigmentation-prone skin.

Recommendations

Use morning and/or evening.
Pair with sunscreen and other brightening actives if tolerated.
Always use sun protection if your skin tends to hyperpigment; we recommend a zinc oxide sunscreen.

Sources

Niacinamide: mechanisms of action and its topical use in dermatology. Draelos ZD, et al. J Cosmet Dermatol. 2023;22(2):505-512. link

Related ingredients

Ascorbic Acid (Vitamin C)Azelaic Acid

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